Turkey Tetrazzini

This easy turkey tetrazzini recipe is a great way to use up Thanksgiving leftovers. It has a rich and creamy sauce and is topped with a buttery breadcrumb topping.

Wooden spatula laying on top of a pan of turkey tetrazzini. Tow servings

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My refrigerator is CRAMMED with Thanksgiving leftovers! Which I guess is a good thing until I have to spend 10 minutes rearranging just to find a place to put a gallon of milk. I love leftovers, but what I love even more is transforming those leftovers into something completely different. 

I know what you’re thinking. The name turkey tetrazzini evokes thoughts of a lady wearing a hairnet standing behind a cafeteria serving line in me too. This recipe is NOT the same gob of mushy noodles and cream of mushroom soup you were served as a kid. The sauce is rich and creamy, the breadcrumb topping is buttery and crispy and it’s a great way to use those Thanksgiving turkey leftovers. This recipe is good ol’ comfort food and no lunch ladies were harmed in the process.

Need another idea for that leftover holiday turkey? Check out this recipe for Turkey Pumpkin Black Bean Chili.

What is a tetrazzini anyway?

Tetrazzini describes any American pasta dish made with diced poultry or seafood mixed with a mushroom cream sauce and parmesan cheese. It is typically served over noodles, such as linguine or spaghetti. It’s named after Luisa Tetrazzini, a famous opera singer of the early 1900s. Tetrazzini was a long-time resident of the Palace Hotel in San Francisco. In 1910, head chef Chef Ernest Arbogast invented Chicken Tetrazzini in her honor.

Ingredients and tools you will need

Creamy turkey tetrazzini is a baked pasta dish that the whole family will enjoy. To make homemade turkey tetrazzini, you will need:

  • 1 package (16 ounces) spaghetti noodles, broken in half – you can also use the same amount of egg noodles.
  • 8 tablespoons unsalted butter, divided
  • 1 medium onion, chopped
  • 1 large sweet red bell pepper, finely chopped
  • 8 ounces sliced fresh mushrooms, washed
  • 1/2 cup all-purpose flour
  • 1 teaspoon salt
  • 6 cups whole milk or heavy cream
  • 1 tablespoon chicken bouillon granules
  • 6 cups cubed cooked turkey meat
  • 1 cup grated Parmesan cheese
  • 1/2 teaspoon cayenne pepper – I love the little kick of heat from the cayenne. Feel free to use more if you like!
  • Ground black pepper, to taste
  • 1 cup panko bread crumbs – Panko breadcrumbs are Japanese breadcrumbs that are crunchier than regular breadcrumbs. They really retain their crunchy texture, even when baked, which is why I love to use it as a topping for this recipe.
  • 9-in. x 13-in. x 2-in. casserole dish or two 8-in. x 8-in. baking dishes
Collage of ingredients needed to make turkey tetrazzini.

How to make turkey tetrazzini

  1. Preheat the oven to 350 degrees. 
  2. Cook the spaghetti in a large pot of lightly salted water, according to the package instructions, until al dente. Drain the pasta and set aside.
  3. While the pasta is cooking, melt four tablespoons of butter in a large stock pot over medium-high heat. Add the onions and sauté until they are tender, about 5-7 minutes. 
  4. Add the mushrooms and red bell pepper and sauté 4-5 minutes longer.
  5. Stir in the flour and salt and stir until blended. 
  6. Gradually whisk in the milk and bouillon. 
  7. Bring the mixture to a simmer and stir for two minutes until the sauce has thickened.
  8. Stir in the diced leftover turkey meat, the Parmesan cheese, and the cayenne pepper. Heat the sauce through and season with additional salt and pepper to your liking.
  9. Add the drained spaghetti and stir to coat with the cheese sauce. 
  10. Transfer everything to a baking dish coated with cooking spray.
  11. Melt the remaining four tablespoons of butter. Once melted, toss the butter with one cup of Panko breadcrumbs.
  12. Spread the Panko breadcrumbs over the top of the casserole.
  13. Bake the turkey casserole for 30-35 minutes until the casserole is heated through and the Panko breadcrumb topping is golden brown.

Storage, freezing, and reheating instructions

Storage. Allow the tetrazzini to cool completely, then cover the top of the casserole dish with a layer of foil or plastic wrap. Store in the refrigerator for up to five days.

Freezing. Uncooked turkey tetrazzini can be stored in the freezer for up to one year. Follow the recipe through step 10. Then cover with foil and freeze. Allow the casserole to thaw before cooking. Right before putting it into the oven, make the Panko breadcrumb topping.

Reheating. Reheat individual servings of tetrazzini in the microwave for 1-2 minutes until heated through. You can also reheat it covered in the oven. Let the casserole sit at room temperature for 20 minutes, then bake at 350 degrees F for 20 minutes until heated through. Halfway through, remove the foil so the breadcrumb topping can crisp up again.

Frequently asked questions

Can I use leftover chicken instead?

Yes, you can use leftover chicken or shredded rotisserie chicken instead. If you are looking for more ways to use up leftover chicken, check out my recipe for chicken spaghetti with Rotel.

Can I use skim milk instead of whole milk or heavy cream?

You can, but your sauce will not be as creamy.

Can I use canned mushrooms?

Yes. Four ounces of drained canned sliced mushrooms is equal to eight ounces of sliced fresh button mushrooms.

Can I use bouillon cubes instead of granules?

Yes. Bouillon granules dissolve faster than cubes, but you can use them. Three bouillon cubes equals the one tablespoon of granules called for in the recipe.

Serving of turkey tetrazzini on a plate with a fork, napkin, and glass of ice water on the side.
Wooden spatula laying on top of a pan of turkey tetrazzini. Two servings have been removed and are sitting on plates to the side.

Easy Turkey Tetrazzini

This easy turkey tetrazzini recipe is a great way to use up Thanksgiving leftovers. It has a rich and creamy sauce and is topped with a buttery breadcrumb topping.
5 from 5 votes
Print Pin Save Recipe Rate
Course: Entrees, Main Courses
Cuisine: American
Prep Time: 7 minutes
Cook Time: 35 minutes
0 minutes
Total Time: 42 minutes
Servings: 8 people
Calories: 330kcal
Author: Lisa B.

Ingredients

  • 1 package (16 ounces) spaghetti
  • 1 medium onion chopped
  • 8 tablespoons butter divided
  • 8 ounces sliced fresh mushrooms washed
  • 1 large sweet red pepper chopped
  • 1/2 cup all-purpose flour
  • 1 teaspoon salt
  • 6 cups whole milk
  • 1 tablespoon chicken bouillon granules
  • 6 cups cubed cooked turkey meat
  • 1 cup grated Parmesan cheese
  • 1/2 teaspoon cayenne pepper
  • 1 cup panko bread crumbs

Instructions

  • Preheat the oven to 350° F.
  • Cook spaghetti according to package directions until al dente. Drain the spaghetti and set aside.
  • Meanwhile, in a large stock pot, melt four tablespoons of butter over medium-high heat. Add the onions and sauté until tender, about 5-7 minutes.
  • Add the mushrooms and red bell pepper. Sauté 4-5 minutes longer or until vegetables are tender.
  • Stir in flour and salt until blended.
  • Gradually whisk in the milk and bouillon. Bring the milk to a simmer and stir for two minutes or until thickened. 
  • Stir in turkey, cheese and cayenne pepper. Heat through. Season with salt and pepper to taste. Remove the pot from the heat.
  • Add the spaghetti noodles to the turkey mixture and mix well.
  • Transfer the casserole to one 9-in. x 13-in. x 2-in. greased baking dish or two 8-in. x 8-in. greased baking dishes.
  • Melt the remaining butter. Toss the butter with the bread crumbs and sprinkle it over the casserole. 
  • Bake, uncovered, for 30-35 minutes or until the casserole is heated through and bread crumbs are golden brown.

Video

Notes

Storage, freezing, and reheating instructions

Storage. Allow the tetrazzini to cool completely, then cover the top of the casserole dish with a layer of foil or plastic wrap. Store in the refrigerator for up to five days.
Freezing. Uncooked turkey tetrazzini can be stored in the freezer for up to one year. Follow the recipe through step 10. Then cover with foil and freeze. Allow the casserole to thaw before cooking. Right before putting it into the oven, make the Panko breadcrumb topping.
Reheating. Reheat individual servings of tetrazzini in the microwave for 1-2 minutes until heated through. You can also reheat it covered in the oven. Let the casserole sit at room temperature for 20 minutes, then bake at 350 degrees F for 20 minutes until heated through. Halfway through, remove the foil so the breadcrumb topping can crisp up again.

Nutrition

Serving: 1serving | Calories: 330kcal | Carbohydrates: 34g | Protein: 19g | Fat: 13g | Saturated Fat: 5g | Polyunsaturated Fat: 2g | Monounsaturated Fat: 4g | Cholesterol: 62mg | Sodium: 656mg | Potassium: 167mg | Fiber: 2g | Sugar: 1g

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5 from 5 votes

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