In a small bowl, combine the salt, pepper, garlic powder, onion powder,
Divide the beef into 8 equal portions and flatten each portion into a thin patty.
Season one side of each patty with half of the seasoning mixture.
Place a cube (or two) of pepper jack cheese in the center of 4 patties. Top each with another patty and seal the edges tightly to enclose the cheese. Shape into thick burger patties.
Season the outside of each patty with the remaining seasoning mixture.
Chill the stuffed patties for 30 minutes before cooking to help them hold their shape.
Preheat a grill or skillet to medium-high heat.
Cook the burgers for 4–5 minutes per side, flipping once, until the internal temperature reaches 160°F.
Remove the burgers from heat and let them rest for 5 minutes before serving.
Serve on buns with desired toppings.
Notes
Be sure to seal the edges tightly to prevent cheese from leaking out.
For extra heat, mix diced jalapeños into the ground beef.
Avoid pressing down on the burgers while cooking to keep them juicy.